Effect of Antioxidant Treatment
on Indicators of Free Radical Action in Workers Exposed to Lead
Machartová V. 1 , Racek J. 2 , Kohout J. 1 , Senft V. 2 , Trefil L. 2
Klinika pracovního LF UK a FN, Plzeň, přednosta doc. MUDr. J. Kohout, CSc. 2 Ústav klinické biochemie a laboratorní diagnostiky LF UK a FN, Plzeň, přednosta prof. MUDr. J. Racek, CSc. |
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Summary:
The authors administered to 36 workers exposed to lead, for four weeks the preparation Prolong
which contains vitamin C,vitamin E, beta-carotene,selenium, zinc and chromium and investigated
the effect on indicators of free radicals. A statistically significant increase of the following occur-
red:superoxide dismutase (p < 0.001), glutathione peroxidase (p < 0.01), an increase of the total
antioxidant capacity (p < 0.01) and an increase of uricaemia (p < 0.05). Based on these results the
authors consider supplementation with antioxidants indicated in workers exposed to lead.
Key words:
Lead - Free radicals - Superoxide dismutase - Glutathione peroxidase - Antioxidant
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