In a prospective randomized study, seven polytraumatized patients were given alanyl-glutamine as Dipeptiven (20 g daily for 10 days) as an additional component to parenteral nutrition administered as All-In-One regimen. Control group consisted of seven patients with comparable APACHE II scores, SOFA and PTS-Hannover scores, who were given parenteral nutrition without glutamine. Parameters of cellular and humoral immunity were assessed before the administration of parenteral nutrition, and subsequently on the 5 th and 11 th day after the trauma. In comparison of both groups, the effects on immunity parameters were not significant. We were not able to prove the definitive effect of immunutrition using glutamine on the severity of SIRS and mortality in the monitored set of patients.

        Key words: glutamine – immunity functions – polytrauma