Oral clonidine in premedication for laparoscopic cholecystectomy – a comparison of different protocols 42 patients scheduled for laparoscopic cholecystectomy were premedicated with clonidine 0,25 mg orally in the morning of the surgery. We did not observe the presumed attenuation of hemodynamic response to capnoperitoneum after clonidine premedication. In comparison between clonidine 0,25 mg orally, 0,15 mg intramuscularly and 2 mcg/kg intravenously or 4 mcg/kg intravenously, all parenteral forms of application resulted in similar responses. We did not observe any difference in fentanyl consumption or the incidence of side effects. The authors recommend routine premedication with clonidine 2 mcg/kg intravenously in 100 mls of normal saline prior to laparoscopic cholecystectomy.

        Key words: clonidine – laparoscopic cholecystectomy – adverse hemodynamic changes