Hepatic fibrosis is a common sequel to most forms of chronic liver disease and an essential com- ponent in the development of cirrhosis. Basic and clinical scientists have increasingly realized the importance of all elements of the liver in fibrogenesis, as well as of structural-functional rela- tionships between liver cells and matrix components of the liver. Important is the recognition that hepatic stellate cells play a central role based on their ability to undergo activation following liver injury of any cause. The study brings about the newest information on pathophysiology of hepatic fibrosis. On the basis of better knowledge of the pathophysiology of fibrogenesis the development of new therapeutic approaches will become possible.

        Key words: Stellate cells - Hepatic fibrosis - Cirrhosis - Cytokines