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  Česky / Czech version Čes. a slov. Farm. 49, 2000, No. 6, p. 306–312
 
Studies of Local Anaesthetics, Part 153: The Relationship Between the Chemical Struc- ture, Physical-Chemical Properties, and Biological Activity in a Series of Piperidinopro- pylesters of Alkoxysubstituted Phenylcarbamic Acids 
SEDLÁROVÁ E., ČIŽMÁRIK J. 

Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
 


Summary:

       Physical-chemical parameters (surface tension, dissociation constant, RF and R M values determined by means of TLC, logarithm of the capacity factor by means of HPLC) of 30 compounds from the group of piperidinopropylesters of o-, m-, p-alkoxyphenylcarbamic acids with local-anaesthetic activity were determined. The correlation chemical structure – physical-chemical properties – local-anaesthetic activity was studied by means of QSAR. The results of the study have d emonstra- ted a linear dependence between log k, RM, and the number of C in the alkoxysubstituent.

        Key words: piperidinopropylesters of alkoxyphenylcarbamic acids – correlation structure – physical-chemical properties – biological activities
       

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