Follicular lymphoma (FL) belongs to the most common forms of non-Hodgkin’s lymphomas. This overview summarizes the important news regarding the therapy of FL from the past 5 years. In principle, in the therapy we can use: watch and wait strategy, radiotherapy, chemotherapy, rituximab, interferon alfa, ibritumomab, tositumomab, autologous hematopoietic stem cell transplantation, allogeneic transplantation, vaccines, and some other new drugs. The order of these therapeutic procedures does not mean this is the sequence in which they should be used. Since FL is a chronic, relapsing disease, a proper procedure(s) should be used in proper patients in a proper sequence. The clinical course of the disease as well as the therapy of FL are variable. Today, have to consider the cost of treatment. Therefore, it is necessary, FL patients are treated in experienced centers.

        Key words: follicular lymphoma, rituximab, interferon alfa, ibritumomab, allogeneic transplantation, autologous hematopoietic stem cell transplantation