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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 48, 2002, No. 3, p. 185-191 |
Potential Predictors
of the Therapeutic Response in Patients with Cryptogernic Fibrotizing Alveolitis Vyšehradský R., Rozborilová E., Straková J., Poláček H., Huťka Z.: Klinika tuberkulózy a pľúcnych chorôb Jesseniovej lekárskej fakulty a Martinskej fakultnej nemocnice, Martin, Slovenská republika, vedúci doc. MUDr. Eva Rozborilová, CSc. Oddelenie lekárskej imunológie a alergológie Martinskej fakultnej nemocnice, Martin, Slovenská republika, vedúci prim. MUDr. Jana Straková, Ph.D. Rádiodiagnostická klinika Jesseniovej lekárskej fakulty a Martinskej fakultnej nemocnice, Martin, Slovenská republika, vedúci MUDr. Hubert Poláček, CSc. Ústav patologickej anatómie Jesseniovej lekárskej fakulty a Martinskej fakultnej nemocnice, Martin, Slovenská republika, vedúci doc. MUDr. Ľudovít Lauko, CSc. |
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Summary: The authors present a clinical observation with the objective to test which objective indicators
make it possible to predict the effect of treatment in patients with cryptogenic fibrotizing alveolitis. Retrospective analysis of the documentation of a longitudinal follow up of 34 patients with
this diagnosis revealed that the presence of fibroproliferative changes on the high resolution CT
image predicts significantly the absence of a therapeutic effect and conversely the absence of
such changes predisposes for significant improvement of pulmonary functions during treatment.
They found also a significant correlation between he ratio of lymphocytes in the bronchoalveolar
lavage fluid and the dynamics of the development of pulmonary functions. The age of estab-
lishment of the diagnosis correlates also significantly with indicators of the therapeutic response.
Based on these results the authors conclude that a favourable therapeutic effect can be expected
in patients without fibroproliferative changes, with a significant lymphopcytosis in the bronchoalveolar lavage fluid and a younger age at the time of manifestation. On the other hand, in
patients with a marked fibroproliferation and absence of alveolitis there is no point in attempting
to influence the disease by pharmacological gents.
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