The objective of the presented work was to find possible predictive factors of pregnan- cy-induced hypertension (PIH) in women with the risk of gestational diabetes (GDM) during pregnancy. A group of women with the risk of development of gestational diabetes was selected because it is known that in women with GDM a hypertension is encountered 2-4 times more frequently than in women without disorders of glucose tolerance during pregnancy. The patients were divided into four groups with regard to the risk of development of hypertension. The exami- nations were made once during the 20th week of gestation. PIH is manifested in the great majori- ty of patients only after the 20th week of pregnancy. All patients were normotensive at the time of examination. During the subsequent course of pregnancy in all patients the diagnosis of gestatio- nal diabetes and pregnancy-induced hypertension was investigated. The investigated parameters were fasting insulin levels during the 20th week of gestation, coagu- lation factors - antithrombin III (AT III), D-dimer, number of thrombocytes. The authors investi- gated also anamnestic data on the presence of type II diabetes and hypertension in close relatives of the patients. Results: No differences were found in the insulin, antithrombin III and D-dimer levels nor in the number of thrombocytes. A significant relationship was revealed between the incidence of hypertension during pregnancy and the family history of the patient. In women where there was diabetes type 2 and hypertension in the family, there was a markedly more frequent incidence of pregnancy-induced hypertension after the 20th week of pregnancy (p > 0.0002) than in the other investigated groups. This work was supported by the Grant Agency of the Ministry of Health of the Czech Republic - grant No. 3320-3.

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