Objective: Comprehensive information about female sexual dysfunctions and possibilities of their treatment. Design: Review article. Setting: Institute for Postgraduate Medical Education, Prague. Methods: Analysis of the literary data (texts in medical journals, monographies, textbooks, internet – „Medline“) and author’s clinical experience. Conclusions: Female sexual dysfunctions are highly prevalent but not well defined and understood. Existing definitions and classifications of female sexual dysfunctions are reevaluated and revised at present. Contemporary classification was expanded to include psychogenic and organic causes of desire, arousal, orgasm and sexual pain disorders. The female sexual response cycle is initiated by neurotransmitters which increase pelvic blood flow, vaginal lubrication, clitoral and vaginal reactivity. The effect of the therapy consists in the stabilization of the hormonal levels. New drugs with vasocongestive effect on genital are discussed.

        Key words: female sexual dysfunction, sexual response cycle, classification, neurogenic mediators, fosphodiesterase inhibitors, estrogen, testosterone