Disturbances of the Plasma Coagulation Defects in Retinal Venous Occlusions
Rehák M.1,2, Krčová V.3, Fric E.1, Slavík L.3, Bábková B.1, Prachařová Z.1, Langová K.4, Řehák J.1
1Oční klinika FN a UP, Olomouc, přednosta doc. MUDr. J. Řehák, CSc. 2Klinik und Poliklinik für Augenheilkunde, Leipzig, přednosta prof. Dr. med. P.Wiedemann 3Hemato-onkologická klinika FN a UP, Olomouc, přednosta prof. MUDr. K. Indrák, DrSc. 4Ústav lékařské biofyziky UP, Olomouc, přednosta prof. Ing. J. Hálek, CSc. |
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Summary:
Occlusions of retinal veins (central and branch) represent multifactorialy-conditioned disease involving presumably older patients,
in whom the changes of retinal vessels caused by hypertension and atherosclerosis present the most important pathophysiological
factors for development of this disease. In last years, the intensive scientific research is focused to the explanation
of the role of the defects of the coagulations cascade. Especially in younger patients, the most often mentioned defect of
the coagulations cascade is called as APC-resistance. Up to 95 % of all patients with APC-resistance are carriers of so called
Leiden mutation.
The aim of our study was to establish the prevalence of the ACP-resistance in 92 patients with central or branch occlusion of
the retinal vein verified by means of angiography treated at the Department of Ophthalmology, Faculty Hospital, Olomouc, Czech
Republic, EU, during the period 1999–2005.The control group consisted of 40 patients without any vascular, eye-related disease.
In the group of patients with occlusion of the retinal vein, the prevalence of the APC-resistance was 10.9 % and in the control
group 5 %. In the group of patients 55 years old and younger the prevalence of the ACP-resistance was 14.3 %, in patients older
than 55 years it was 5.6 %. According to the relatively small groups of patients, the established difference did not reach the
level of statistical evidence. Results of our study confirmed the conclusions of previously published papers that the prevalence
of the APC-resistance is not significantly higher in patients with retinal vein occlusion according to the prevalence in controls.
Key words:
retinal venous occlusion, trombophillia, ACP-resistance, Leiden-mutation
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