Intravenous Treatment of Pospartal Anemia with Trivalent Ferrum
Preparation
Binder T.1, Záhumenský J.2, Feldmár P.1, Dvorská M.2, Zmrhalová B.1
1Gynekologicko-porodnická klinika 2. LF UK a FN Motol, Praha, přednosta doc. MUDr. L. Rob, CSc. 2Gynekologicko-porodnická klinika l. LF UK a FN Bulovka, Praha, přednosta prof. MUDr. M. Halaška, DrSc. |
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Summary:
Aim of the study: To assess the effectivity and safeness of intravenous treatment of pospartal anemia with
trivalent ferrum preparation.
Type of the study: Prospective randomized study.
Seat: Department of Obstetric and Gynecology 2nd Medical Faculty Charles University and Teaching
Hospital Motol, Prague, and Department of Obstetric and Gynecology lst Medical Faculty and Teaching
Hospital Bulovka, Prague.
Methods: 500 mg of sacharose ferric oxide (Venofer) was intravenously administered in two days regimen
to 50 women with clinical and lab signs of postpartal anemia. The effect of administered drug was
determined by comparsion of values of red blood count recovered before the treatment, 2nd or 3rd day
post administration and two weeks later. The serum values of soluble transferrin receptors and ferritin
were observed as markers of iron cell saturation and body iron reserves, too. Integral part of the study
was the monitoring of adverse events during the treatment.
Results: Venofer came in sight as effective drug in the treatment of pospartal anemia and could
become as the alternative to blood transfusion in mid-severe cases. It should be emphasized that we
have not encountered any serious adverse event with intravenous trivalent saccharose ferric oxide
treatment.
Key words:
postpartal anemia, intravenous treatment, saccharose ferric oxide (Venofer)
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