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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Čas. Lék. čes., 2007, 146, pp. 45–47. |
Prognostic Impact of Matrix Metalloproteinases 2,9, and 11 in Stromal
Cells Stage I Non-small Cell Lung Cancer Dráč P., 1Klein J., 3Tichý T., 2Kolek V., 3Škarda J. II. chirurgická klinika FN, Olomouc 1I. chirurgická klinika FN, Olomouc2Klinika tuberkulózy a respiračních nemocí FN, Olomouc 3Ústav patologie LF UP, Olomouc |
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Summary: Background. Matrix metalloproteinases (MMPs) belong to proteolytic enzymes. Degradation of the cell
basement membrane and the extracellular matrix is one of their functions. In malignant tumors they can
hypothetically contribute to the invasion and metastasis formation. They are mostly produced by stromal
cells (fibroblasts and endothelial cells) as a response to the presence of tumor cells. MMP-2 (gelatinase
A), MMP-9 (gelatinase B) and MMP-11 (stromelysin 3) are often mentioned in regard to Non-small Cell
Lung Cancer (NSCLC).
Methods and Results. The relation between the expression of the above-mentioned matrix metalloproteinases
in stromal cells and the cancer-related survival in 80 patients after curative resection of
NSCLC in stage I according to TNM was studied. The expression of MMP-2 was associated with
cancer-related survival but without significant correlation. No correlation was found in MMP-9. There
was a statistically near-significant relation between the expression of MMP-11 and cancer-related
survival.
Conclusions. The expression of MMP-11 in stromal cells in surgically treated NSCLC patients in stage
I appears useful for evaluation of their prognosis.
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