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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
| Journals - Article | |
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| Česky / Czech version | Čes. Radiol., 55, 2001, No. 2, p. 105-108 |
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Effect of the Intratracheal Administration of Iomeprol on the Glycoconjugate Composition in the Secretion of Goblet Cells in the epithelium of
the airways
Vajner L., Konrádová V., Uhlík J., Zocová J., Tůma S. Ústav histologie a embryologie 2. LF UK, Praha, přednostka prof. MUDr. V. Konrádová, DrSc. Klinika zobrazovacích metod 2. LF UK a FN v Motole, Praha, přednosta doc. MUDr. J. Neuwirth, CSc. Ústav aplikované matematiky a výpočetní techniky PřF UK, Praha, přednosta doc. RNDr. J. Ježek, CSc. |
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Summary: Authors studied experimentally changes of the glycoconjugate composition in the secretion of
tracheal goblet cells after intratracheal administration of 0.5 ml triiodinated contrast agent (Iomeron 300, Bracco-Byk Gulden). Specimens for both conventional and lectin histochemistry were
collected 40 minutes after exposure. In comparison with control animals, a decrease occurred in the
percentage of the goblet cells containing acidic sialylated glycoconjugates. The percentage of the
goblet cells containing neutral glycoconjugates remained unchanged. The intratracheal administration of Iomeron 300 evoked statistically significant ( a < 0.01) changes in the percentage of the
tracheal goblet cells containing acidic sialylated glycoconjugates.
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