-Heavy chain disease
Tichý M.1, 5, 6, Maisnar V.4, 6, Stulík J.1, Urban P.2, Adam Z.3, Kadlčková E.2, Vávrová J.5, Palička V.5, Jebavý L.1, 4, Kodet R.7, Hájek R.6, 3
1Fakulta vojenského zdravotnictví UO, Hradec Králové 2Oddělení klinické biochemie, Baťova nemocnice, Zlín3Interní hematoonkologická klinika FN a LF MU, Brno-Bohunice4II. interní klinika – Oddělení klinické hematologie FN a LF UK Hradec Králové5Ústav klinické biochemie a diagnostiky LF UK a FN Hradec Králové 6Česká myelomová skupina 7Ústav patologie a molekulární medicíny 2. LF UK a FNM, Praha |
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Summary:
We report the new case of -heavy chain disease. 63-year old female was successively ill of carcinoma vulvae,
Hodgkin lymphoma, -heavy chain disease and acute myeloid leukemia. We determined monoclonal heavy chain in
serum of the patient with method immunofixation electrophoresis on agarose (HYDRAGEL 41F, SEBIA, Paris) and with
Capillarys Immunotyping (Capillarys 2, SEBIA, Paris). Concentration of -heavy chain in the patient was very high –
34.9 g/l. Molecular weight of heavy chain was determined by 2-dimensional gel electrophoresis and it was 53 kD.
Monoclonal -heavy chains and light chains Ig were not determined in urine in our case of -heavy chain disease.
Key words:
heavy chain disease , capillary zone electrophoresis, 2-dimensional gel electrophoresis.
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