Diagnosis and Treatment of Childhood Mature B-acute Lymphoblastic Leukaemia in
the Czech Republic in 1990 –2000
Starý J.1 ,Gajdoš P.2 ,Hrušák O.3 ,Pospíšilová D.4 ,Hak J.5 ,Kopečná L.6 ,Michalová K.7
1 II.dětská klinika UK 2.LF a FN Motol,Praha, 2 Státní zdravotní ústav,Praha, 3 Imunologický ústav UK 2.LF a FN Motol,Praha, 4 Dětská klinika FN Olomouc, 5 Dětská klinika FN Hradec Králové, 6 I.dětská interní a onkologická klinika FN Brno, 7 Centrum nádorové cytogenetiky VFN a UK 1.LF,Praha |
|
Summary:
Acute lymphoblastic leukaemia (ALL)derived from mature B-cells is in fact generalized Burkitt ´s
lymphoma.Leukemic blasts are classified as L3 according to the FAB morphological classification.They
are characterized by the presence of the surface immunoglobulins,most often IgM,and by a high
proliferative rate.Current treatment comprising short blocks of intensive chemotherapy improved
remarkably the prognosis of this rare disease.Between VI/1990-XII/2000,ALL was diagnosed in 671
children and adolescents aged 0 –18 years in the Czech Republic.B-ALL was found in 9 children (1.3 %).
Complete remission was achieved in 77.8 %children.Four patients (44.4 %)suffered from early renal
failure which developed as a result of the tumour lysis syndrome.Neither death in remission nor relapse
were seen in this small group of patients.With a median follow-up of 3,7 years,the probability of
event-free-survival is 75 %(SE 15 %).Therapeutic results of B-ALLin the Czech Republic are comparable
to the results of the leading leukaemic study groups in the world.
Key words:
acute lymphoblastic leukaemia,mature-B-cells,treatment,children
|
