The authors conducted a pilot study to assess the prevalence of hyperhomocysteinaemia in 49 persons (24 men and 25 women) with ischaemic stroke in their medical history. Mean age of the study population was 62.2 years (33-86 years). Normal homocysteinaemia (up to 15.99 ~xnoUl) was found in 36 persons (prevalence 0.735), hyperhomocysteinaemia was found in 13 persons (prevalence 0.265), out of which mild and medium hyperhomocysteinaemia esere present in 12 and 1 person (prevalence 0.245 and 0.02, respectively). The second objective of the study was verification of the practical applicability of high-power liquid chromatography according to Araki et al. In the article the significance of hyperhomocysteinaemia especially in combination with other risk factors is discussed and the importance of its early detection in the risk population is stressed. Limits of the practical applicability of the used chemical analysis are mentioned.

        Key words: hyperhomocysteinaemia, ischaemic stroke, high-power liquid chromatography