The purpose of this experimental study was to observe the response of surrounding tissues to long-term presence of coated titanium implants under loading. The protective layer based on hydroxylapatite was created by the method of pulsed laser deposition with KrF excimer laser on the kernel from titanium alloy. The coating thickness was about 1 mm. Implants were inserted into the mandible of minipigs up extracted premolars. Up 14 weeks of healing without loading the metal-ceramic crowns were cemented and implants were moved into the occlusion. Six months after the crown application the experimental animals were sacrificed and from the bone blocks with implants were manufactured microscopic ground sections. The implant position in the bone was determined by radiovisiography. The bone structure around implant was viewed in microscope using the transmitted light. Observation after six months long functional loading acknowledge the presence of newly formed bone around of all implants. At none of samples were found any osteoclasts, macrophages or regressive changes.

        Key words: dentistry – dental implants – hydroxylapatite – titanium – histology