Enteroviral infections are of the most common infections in the human population. Circulation of these viruses is high in population and they cause a wide range of clinical syndromes in human. The aim of this study was to compare the coxsackievirus circulation intensity in the population of the Slovak Republic during the period of last 23 years and to identify changes also in relation to modification in polio vaccination scheme. Marker indicating suffered infection was the presence of virus specific antibodies, assessed by means of the virus-neutralizing test. High frequency of infections by all studied coxsackievirus serotypes was confirmed in this study. Consecutive decrease in rate of anti-coxsackievirus antibodies was identified. This may be a consequence of hygiene standard improvement. After modification of immunization scheme (2004/2005) the decrease has been stopped, a mild increase of seropositivity to all studied serotypes was observed, respectively

        Key words: enteroviruses, circulation, coxsackievirus, virus neutralization test