Intrauterine Growth Retardation and Fetal Origin of Diseases at the Adult
Age
Kytnarová J.1, Zlatohlávková B.3, Fedorová M.3, Malošková G.3, Kršek M.2
Klinika dětského a dorostového lékařství VFN a UK 1. LF, Praha1 přednosta prof. MUDr. J. Zeman, DrSc. III. interní klinika VFN a UK 1. LF, Praha2 přednosta prof. MUDr. Š. Svačina, DrSc., MBA Gynekologicko-porodnická klinika VFN a UK 1. LF, Praha3 přednosta prof. MUDr. A. Martan, DrSc. |
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Summary:
The reasons for fetal growth restriction are heterogeneous. It was postulated that
low birthweight together with postnatal environmental factors might increase the risk
for number of diseases in adulthood, i.e. hypertension, ischaemic heart disease or diabetes
mellitus type 2. Pathophysiology of this relationship is not fully understood, but
it is evident, that pre- and postnatal growth and subsequent risks are modulated by different
metabolic changes and genetic factors. According to programming hypothesis intrauterine
adaptation to disadvantageous influences leads to long-term metabolic and
endocrine alterations. IGF-I, IGF-II and their binding proteins (IGFBP) system as well
as certain polymorphisms in IGF-I promotor gene might be possible candidates in explaining
the link between intrauterine growth retardation and some of the diseases in
adulthood.
Key words:
intrauterine growth retardation, low birthweight, IGF-I, IGF-II, IGF binding
proteins, IGF-I gene polymorphism
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