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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
Journals - Article | |
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Česky / Czech version | Vnitř. Lék., 47, 2001, No. 4, p. 245-249 |
The Importance of Leptin in Oncology - Hypothesis or Facts? Gaja A., Churý Z Oddělení klinické hematologie Masarykova onkologického ústavu, Brno, ředitel doc. MUDr. Jan Žaloudík, CSc. |
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Summary: Leptin was described as a protein produced mostly by adipocytes which participates in regulation of caloric intake. This protein has further many physiological regulatory functions especially
in hematopoesis and reproduction. The role of leptin in diseases is also considered. Maybe leptin
is a part of the pathogenic mechanism or its metabolism can be influenced secondary to disease.
Malignant tumours are the important area where leptin can acts. This imagination is supported
by recent in vitro studies and some clinical observations. It is consider that some parameters of
leptin metabolism can serve as usable marker for diagnosis and monitoring of some malignant
tumours - especially breast cancer or some types of leukemia. The authors give a review of actual
information of leptin metabolism changes in oncological diseases.
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