We report a case of an 86-year-old female with a tubulo-squamous polyp of the vagina. Grossly, the polyp measured 2 x 1.5 x 1 cm. Histologically, it was composed of well-circumscribed nests of squamous cells with bland nuclei. Some of the squamous nests showed central spaces filled with necrotic debris. Small tubules were present at the periphery of some of the nests, and there were a few tubules unassociated with the squamous nests. Furthermore, several larger mucinous glands, some with apparent squamous metaplasia, were present. The stroma was fibrous and rather hypocellular. Surface of the polyp was covered by intact squamous epithelium, which was not connected with the underlying lesion. The recently described tubulo-squamous vaginal polyp represents a distinctive entity. To the best of our knowledge, only one study describing a series of ten cases has been reported in the literature to date.

        Key words: tubulo-squamous – polyp – vagina