 |
CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
| Journals - Article | |
 |
 |
| Česky / Czech version | |
|
A cure of severe fortn of haemophilia A by Hver transplantation CHARVÁT J.i, VYCHODIL P.2, ADAMEC M.3, TRUNEČKA P.4, DULÍČEK P.5, SMRČKOVÁ I.1, PAGÁČOVÁ L.1 lÚsek laboratorních metod, IKEM, Praha, vedoucí doc. MUDr. Antonín Jabor, CSc. 2Klinika anesteziologie, resuscitace a intenzivní péče IKEM, Praha, přednosta MUDr. Eva Kieslichová 3Klinika transplantační chirurgie IKEM, Praha, přednosta doc. MUDr. Miloš Adamec, CSc. 4Klinika hepatogastroenterologie IKEM, Praha, přednosta doc. MUDr. Julius Špičák, CSc. 5II. interní klinika - Oddělení klinické hematologie Fakultní nemocnice a Lékařská fakulta v Hradci Králové, přednosta prof. MUDr. Jaroslav Malý, CSc. |
|
Summary: A 62 year old patient with a severe form of haemophilia A underwent liver transplantation for hepatocellular carcinoma. Before the transplantation, a single bolus dose of 4 000 units of factor VIII concentrate was applied to the patient. During the transplantation, the patient received 17 transfusion units of fresh frozen plasma. Over the course of the transplantation and in the following days, factor VIII blood levels oscillated between 120 and 240 %. Recurring abdominal bleeding from the 6th to 17th postoperative day was not cau-sed by a blood coagulation disorder. Unlike other described cases, our patient was not given factor VIII concentrate during the operation. A single bolus dose of the concentrate and fresh frozen plasma during the course of transplantation was enough to maintain adequate factor VIII levels until synthesis of endogenous factor VIII commenced in the transplanted liver.
|
|
|
Order this issue
|
|
| BACK TO CONTENTS | ||
| | HOME PAGE | CODE PAGE | CZECH VERSION | |
| © 1998 - 2008 CZECH MEDICAL ASSOCIATION J. E. PURKYNĚ |
| Created by: NT Servis, s.r.o., hosted by P.E.S. consulting, s.r.o. |
| WEBMASTER |