Modulation of the function of nuclear receptors PPAR (peroxisome proliferators activated receptors) is one of most attractive fields in pharmacological research. Today it represents an important part of the clinical use of antidiabetic and hypolipidemic drugs (PPAR alpha and gamma). Significant development is expected in PPAR beta modulation and in the complex intervention of several receptor families (double and triple sensitisers) Drugs influencing PPAR will be used in future in dermatology, surgery, obesitology, oncology, gastroenterology and also in neurology and psychiatry

        Key words: diabetes, atherosclerosis, double sensitisers, triple sensitisers, wound healing, anti-inflammatory effect, neuropsychiatry.