Introduction: The new glucometer Advance (Hypoguard), and the new generation of capillary teststrips Advance Micro-draw for testing blood glucose concentration (BG) with minimum amount (1.5 µl) of blood have been recently introduced in the Czech Republic. Objective: To assess and to compare the precision of two glucometer systems (Advance and Optium) in the range of hyper- and hypoglycaemia. Material and Methods: BG was estimated in heparinized venous blood (sample 1: BG 9.0–15.0 mmol/l, sample 2: BG 1.1–4.2 mmol/l) by means of 19 glucometers Advance and 9 glucometers Optium. In each series, 570 estimations on 19 glucometers Advance and 270 estimations on glucometer Optium were evaluated. Test strips Advance Micro-draw (Lot No 6004), and Optium G3 (Lot No 51 322) were used. The precision of systems was assessed by means of standard deviations of results in tested systems. Statistical analysis was performed by means of programme SPSS, v. 10.1.; P

        Key words: glucometer Advance, strips Advance Micro-draw, glucometer Optium, precision, selfmonitoring.