The authors describe an illness in a man, who first developed meningitis caused by Candida albicans and subsequently they found in CSF a pattern typical for tumour meningeosis according to cytological examination of melanoma origin. The presence of Candida albicans was confirmed microscopically and by cultivation. The melanoma was confirmed post mortem by immunohistochemical cytological investigation, S100 protein and HMB 45 being positive. Neither intravital nor post mortem investigations revealed a primary source of melanoma. The authors considered the role of melanoma on impaired immunity that allowed the opportunistic infection caused by Candida albicans to develop and the possibility of primary malignant melanoma of the meninges.

        Key words: meningitis caused by Candida albicans, primary malignant meningeal melanoma, cerebros- pinal fluid