Cerebrospinal fluid (CSF) fistulas, especially of the anterior skull base and pyramids, are potentially life threatening conditions. The passage of bacterial flora and bacterial meningitis is the leading cause ofmorbidity and mortality in these cases. In some cases, anamnesis and clinical conditions are not typical and it is necessary to prove the presence of CSF in nasal or ear secretions. Glucose testing is only a basic test. Detection of β2-transferrin is the „gold standard“ in detection of liquorrhea. Isoelectric focusing is used for such detection, but it is a quite difficult and time consuming laboratory method. β-trace protein (prostaglandin-D-synthase) is very important protein found in CSF. For the detection imunonefelometric assay can be used which is an easier, faster,more sensitive and more accessible method. Detection of β-trace protein is a very useful method for the screening of CSF fistulas. Our liquorrological laboratory has been using this test since 2002. Average concentration of BTP in blood serum of our patients is 0.58 (± 0.20) mg/l, and in CSF 20.80 (± 4.11) mg/l.

        Key words: liquorrhoea, glucose testing, β2-trace protein, immunonefelometric assay.