Objective: To present a review of a novel transdermal contraceptive patch containing norelgestromin (150 g/d) and ethinylestradiol (20 g/d). Design: Review article. Setting: Department of Gynecology and Obstetric, 1st Medical Faculty and General Faculty Hospital, Prague. Results: The contraceptive patch exhibits favourable pharmakokinetic profile, maintaining efficacious serum hormone concentrations under varying conditions and without peaks and through characteristic of oral dosing. Efficacy, cycle control, tolerability and side effect profile were comparable to an established oral contraceptive. Compliance with the weekly administered contraceptive patch was significantly better than with an oral contraceptive. The reliability of adhesion of the patch is very high and consistent even under varying conditions (heat, humidity, exercise).

        Key words: transdermal contraception, contraceptive patch, norelgestromin, ethinylestradiol