We assessed the influence of renal replacement therapy on selected lipid parameters in subjects with dyslipo- proteinaemia, treated by regular haemodialysis. In 23 dialysed patients we compared the effect of a single haemodialysis (HD) employing cuprophane membranes with haemodiafiltration (HDF) through high-flux poly- sulphone membranes. The percentages of expressed acute lipid changes following HD and HDF had, in most cases, an analogous trend. Statistical significance was achieved in Lp C-III concentration +10.28% (±19.45) during HD vs – 5.59% (±10.33) in HDF, p < 0.001. In both methods the level of apoproteins A-I and B increased together with an increasing concentration of Lp A-I particles. The level of total cholesterol, non-HDL and HDL cholesterol, also rose. On the other hand, triacylglycerols mildly fell and analogously the Lp C-III particle concentrations changed. The proportion of Lp C-III non-B increased with a parallel fall in Lp C-III B particles. These changes of lipoprotein and apoprotein levels following HD and HDF develop secondarily in response to the influence of haemoconcentration during intentional ultrafiltration and also enhanced lipoprotein metabo- lism following the administration of heparin. In HDF the absorption of LPL inhibitors on the surface of high-flux membranes can be demonstrated. We also allowed for the possibility of influencing renal dyslipoproteinaemia by HDF treatment over a period of 8 weeks. Control lipid level evaluation did not exhibit favourable significant results.

        Key words: kidney failure, renal dyslipoproteinaemia, dialysis membrane.