![]() |
CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
Journals - Article | |
![]() |
![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Česky / Czech version | Vnitř. Lék., 49, 2003, No. 11, s. 869 - 873 |
IgA Nephropathy: Modern Laboratory Diagnostics and
Value of Renal Biopsy Matoušovic K., Martínek V. Interní klinika 2. lékařské fakulty UK a FN Motol, Praha, přednosta doc. MUDr. Milan Kvapil, CSc. |
|
Summary: IgA nephropathy is the most frequent primary glomerulonephritis worldwide. At its onset, the
most common laboratory sign is isolated haematuria often accompanied with mild proteinuria
(up to 1.5 g/24 h). The disease displays a progressive course with end-stage renal disease occurring
in up to half of patients 20 years after onset. Diagnosis is established by immunofluorescent
microscopy of a renal biopsy specimen. Discoveries in the past decade on the pathogenesis of IgA
nephropathy together with complex evaluation of its clinical presentation enable to establish
diagnosis with a satisfactory degree of probability even without biopsy. IgA nephropathy patients
display increased or borderline serum IgA levels; increased serum levels of IgA fraction with
degalactosylated O-linked side sugar chains; increased serum levels of anti-N-acetylgalactosamine
antibodies; increased levels of circulating immune complexes composed of IgA1 complexed with
IgG or IgA1; increased serum levels of circulating complexes composed of IgA and fibronectin;
and frequent occurrence of the rheumatoid IgA factor. Clinical use of these still generally unavailable
methods would reduce the renal biopsy indication in patients with isolated or predominant
haematuria.
|
|
Order this issue
|
BACK TO CONTENTS | ||
| HOME PAGE | CODE PAGE | CZECH VERSION | |
© 1998 - 2008 CZECH MEDICAL ASSOCIATION J. E. PURKYNĚ |
Created by: NT Servis, s.r.o., hosted by P.E.S. consulting, s.r.o. |
WEBMASTER |