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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 48, 2002, No. 3, p. 259-263 |
Richter´s Syndrome (Bimorphic Malignant Lymphoma) Holomáňová D.,Varga A., Mistrík M., Sakalová A., Kotouček P., Plank L., Szépe P Klinika hematológie a transfuziológie FN, Bratislava, prednosta prof. MUDr. A. Sakalová, DrSc. HTO, Nové Zámky, prednosta MUDr. A. Varga Ústav patológie Martinskej fakultnej nemocnice a JLF UK, Martin, prednosta prof. MUDr. L. Plank, DrSc. |
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Summary: Two distinct morphological types of malignant lymphoma in the same patient occur mostly due to
transformation of a low grade lymphoma (CLL) into a large - cell non-Hodgkin lymphoma (highgrade lymphoma). Later reports have brough evidence of a clonal relationship between CLL and
supervening NHL. The Richter´s syndrome was found to be more frequent in patients with CLL
displaying either multiple chromosomal aberrations or monoclonal gammapaties. In the last two
decades reports have evidenced the existence of two types of the Richter´s syndrome: one, the
“classical” as a terminal event in a long evolving CLL, the other “variant” as the first clinical
manifestation of a previously unrecognized subclinical CLL. Aggressive chemotherapy of CLL
play a role in transformation of CLL to Richter´s syndrome.
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