Dysfunction of gastrointestinal tract affects about 30-60 % diabetic patients. The gastroparesis occurs only in part of patients. Dysfunction has different manifestations from quantitative and qualitative changes of motility to alterations of visceral sensitivity. Pathogenesis of the disturbances is multifactorial - autonomic neuropathy, quality of metabolic control, function of enteric nervous system and others. Scintigraphy is a standard for making diagnosis. Due to its multifactorial natural history, therapy is difficult. It encompasses dietary modifications, good control of diabetes, prokinetic drugs. New drugs and treatment techniques are beeing developed.

        Key words: Diabetic gastroparesis - Prokinetics - Pathogenesis - Therapy