Retrospective analysis of 105 patients who underwent high-dose chemotherapy BEAM following autologous stem cell transplantation because of Hodgkin´s (29) or non-Hodgkin´s lymfoma (76) demonstrated association between rapidity of platelet engraftment and count of CD34+ cells in the graft. Increase of neutrophils was significantly accelerated after higher total dose of filgrastim and association with retarded normalization of platelets was observed on the other hand. Increased risk of death, mainly by progression of the disease, was associated with higher count of transfused bags. One may suggest, in accordance with some reports, significant increase of CD34+ cells over 5,0x106/kg in graft already does not significantly shorten the interval of severe cytopenia. After haematopoietic progenitor cells riched graft transfers, administration of filgrastim probably more than proliferation potentiates their maturation to granulocytes, obviously to the detriment of megakaryocytopoiesis with slowing down platelet normalization. Higher count of transferred bags and increased risk of death association correspond to difficult stem cells mobilization from refractory, relapsing and often pretreated patients. Their prognosis is due to lymfoma unfavourable, regardless of transplantation has been performed.

        Key words: autologous transplantation, haematopoietic stem cells, lymfoma, filgrastim, engraftment, remission, relapse.