Antidepressant Therapy: Choice Based on CYP2D6 Activity and Gender
Žourková A.1, Hadašová E.2, Pulkrábková L.1, Robeš M.1, Ravčuková B.3
Psychiatrická klinika LF MU a FN, Brno, přednostka prof. MUDr.E. Češková, CSc.1 Farmakologický ústav LF MU, Brno, přednostka prof. MUDr. A. Šulcová, CSc.2 Oddělení lékařské genetiky FN, Brno, přednostka prim. MUDr. R. Gaillyová3 |
|
Summary:
The choice of a suitable antidepressant for maintenance therapy depends not only on the efficacy of
the drug to be administered, but on its metabolization and the gender of the patient, his/her age
and/or other medication, too. The goal of the study was to compare the therapeutic effect and incidence
of sexual dysfunction in patients in paroxetine maintenance therapy treating a depressive
and/or anxiety disorder with respect to gender and CYP2D6 activity. The findings support equal
CYP2D6 activity in both genders and equal antidepressant effect disregarding the gender and
CYP2D6 activity.
A unique finding of the study is varying incidence of sexual dysfunction depending on CYP2D6 activity
within the group of female patients.
Key words:
antidepressants, CYP2D6, gender, efficacy, sexual dysfunction.
|
