In patients with idiopathic intestinal inflammations the hypercoagulation is one of the potential factors in the development of the disease and its complications. In a group of 16 patients in the asymptomatic stage of Crohn’s disease after resection of the gut on account of stenosis, the authors assessed the prevalence of basic indicators of hypercoagulation. The authors did not reveal a higher incidence of inborn factors of hypercoagu- lation – Leiden’s mutation and allele 20210A prothrombin. They did not prove a reduced level of C and S protein and antithrombin III. As compared with the control group of healthy subjects the plasma fibrinogen level was not elevated. The absence of genetically conditioned factors of hypercoagulation which play a decisi- ve part in the development of thromboembolic complications, normal levels of protein C, protein S, antithrom- bin III and fibrinogen in our groups of patients provide indirect evidence against the participation of hypercoagulation in the etiology of the development of complicated Crohn’s disease.The finding of a higher fibrinogen level may be a secondary non-specific manifestation of chronic inflammatory activity.

        Key words: Crohn’s disease – Leiden and prothrombin mutation