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  Česky / Czech version Čes. Radiol., 57, 2003, No. 3, p. 111–129.
 
Comprehensive Approach to the Treatment of Malignant Liver Tumours. State of the Art 
Válek A. V.1, Boudný J.1, Kiss I.2, Kala Z.3 

Radiologická klinika, FN Brno - Bohunice1 přednosta doc. MUDr. A. V. Válek, CSc. Oddělení klinické onkologie, FN Brno - Bohunice2 primář MUDr. I. Kiss Chirurgická klinika, FN Brno - Bohunice3 přednosta prof. MUDr. J. Vomela, CSc.
 


Summary:

       Treatment of hepatic metastases is a problem. At the time of diagnosis resection of the liver is possible in 15–30% patients. In this group however in 30–40% patients within 16–24 months recurrence of the disease occurs in the remainder of the liver. Despite this resection is generally considered the only way to cure these patients. The objective of other methods is according to common practice to prolong the rest of life of these patients. Non-surgical approaches to these patients improved and many workers consider them an alternative of resection. The position is similar in patients with primary malignant liver tumours, in particular hepatocellular carcinoma. In adults however hepatocellular carcinoma (HCC) is in as many as 80% inoperable (in particular due to the freqeunt associated cirrhosis of the liver or multicentric character of the tumour). Although in these patients liver transplantation is a possible alternative, the majority of patients receive systemic chemotherapy. The endeavour of a multimodal approach to the treatment of malignant liver processes is to offer these patients optimum care and achieve thus not only prolongation of life but to cure the greatest possible proportion of patients where surgery is not possible. High standard treatment of liver metastases can followonly after a very good andaccurate diagnosis with a high sensitivity and specificity which from the aspect of contemporary medicine implies in diagnoses of livermetastases 98% and 94% resp. These results can be achieved only by a combination of procedures which include in addition to sonography, CT andMR(with the use of specific contrast substances) in particular CTA and CTAP.

        Key words: liver tumour - chemoembolization - locoregional chemotherapy - Lipiodol
       

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