Objective: To evaluate two years experience with Chemoembolization of unresectable malignant liver tumours. Materiál and method: Between June 1999 and June 2001 Chemoembolization was performed in 16 patients with unresectable liver tumours. They were 4 women and 12 men, average age 59.5 years (49 - 72 years). 5 patients had histologically proved hepatocellular carcinoma, S patients had metastases of colorectal carcinoma, two metastases of adenocarcinoma of the stomach and 1 patient had metastases of gallbladder adenocarcinoma. Chemoembolization was performed selectively or superselectively with a suspension of Lipiodol (S - 15 ml) and doxorubicine (max. 50 mg). Chemoembolization was followed by gelatin sponge embolization in S patients. Results: In a group of 5 patients with hepatocellular carcinoma three showed regression in tumour size on CT scans and a decrease in sernm alpha-fetoprotein level. In one of these three patients progression in tumour size on CT scans and elevation of sernm alpha-fetoprotein level was seen 9 months after Chemoembolization. Stabilization of the tumour size and sernm alpha-fetoprotein level were observed in the remaining 2 patients. One of these two patients showed progression of the disease 12 months after Chemoembolization. 2 patients from the group with hepatocellular carcinoma died 6 and 17 months after Chemoembolization. In the group of the 11 patients with liver metastases the size of lesions receded on CT scans in 1 patient, remained stable in 9 and progressed 1 month after Chemoembolization in 1 patient. From the 9 patients with stabilized lesions 3 developed progression 2, 3 and 6 months after Chemoembolization. Tumour markers decreased in 2

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