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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Čes. a Slov. Neurol. Neurochir., 61/94, 1998, No. 6, p. 296–302. |
Polymorphism of Apolipoprotein E in Families with an Early Ischaemic Cerebrovascular Attack Vaverková H., Vlachová I., Novotný D., Škopková Z., Urbánek K., Hubáček J., Poledne R., Bartek J. 1 III. interní klinika, LF a FN, Olomouc 2 Neurologická klinika, LF a FN, Olomouc 3 Oddělení klinické biochemie, FN Olomouc 4 Laboratoř pro výzkum aterosklerózy, IKEM, Praha |
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Summary: Apolipoprotein E plays a crucial role in the cholesterol and triglyceride metabolism
and has an impact on their blood concentrations. The polymorphism of apolipoprotein E is
one of the main genetic factors responsible for familial predisposition for ischaemic
heart disease. In cerebrovascular attacks the polymorphism of apolipoprotein E was
investigated so far only very rarely and it is therefore the objective of the present work
to evaluate its relation to early ischaemic (atherotrombotic) cerebrovas- cular attacks.
To this end a group of 71 subjects was examined (38 men and 33 women) after an early
ischaemic cerebrovascular attack (at the age under 55 years), 55 of their siblings and 88
children of these patients. The findings were compared with a control group of healthy
subjects with a negative family history of early atherosclerosis, matched for age and sex.
The findings were also compared with a random sample of the Czech population examined
within the MONIKA project (289 subjects). In the patients the authors found, as compared
with the control group, a lower incidence of genotype Î3/3
(59.1% vs. 80.1%, p<0.05). In women genotype Î3/4 was more
frequent (33.3% vs. 11.9%, p<0.05), in men genotype Î2/3
(21.1% vs. 4.5%, p<0.05). The more frequent incidence of genotype Î3/4
in women persisted also on comparison with a random population sample (33.3% vs. 17.6%, p
= 0.05). Women with allele Î4 had, as compared with allele Î2, a higher concentration of total cholesterol, LDL cholesterol and
fasting bood glucose while men with allele Î4 had only a
significantly higher apolipoprotein B level and blood glucose level on fasting, as
compared with allele Î2. Conclusions: The polymorphism of
apolipoprotein E is very probably a genetic predisposing factor of early ischaemic
cerebrovascular attacks in particu- lar genotype Î3/4 in
women. Key words: apolipoprotein E polymorphism, ischaemic cerebrovascular attack, stroke,
lipoproteins, apoprotein
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