Objective: To control the occurrence of the antibodies against Staphylococcal type A and type B enterotoxin in gynaecological patients and in selected patients to determine the thermodynamic parametres of antibodies against Staphylococcal enterotoxins in their blood samples. Design: Retrospective clinical study. Setting: 2nd Department of Obstetrics and Gynaecology, P. J. Šafárik University Košice, Slovak Republic; Research Institute of Veterinary Medicine, Košice, Slovak Republic; Department of Microbiology and Immunology, University of Veterinary Medicine, Košice, Slovak Republic; Department of Food Microbiology and Toxicology, Food Research Institute, University of Wisconsin,Madison, USA. Methods: The occurrence of antibodies against Staphylococcal type A and type B enterotoxin was determined in 68 patients hospitalized in Department of Obstetrics and Gynecology in Košice. Results: The occurence of antibodies against Staphylococcal enterotoxins was determined by radioimmunoassay (RIA) in blood samples of 45 (66 %) patients. The antibodies against Staphylococcal type A enterotoxin were determined in 36 (53 %) patients and the antibodies against Staphylococcal type B enterotoxin were determined in 9 (13 %) patients. The antibodies against both type A and type B enterotoxins were determined simultaneously in blood samples of 10 % of all patients. The thermodynamic parameters of the antibodies were determined in 5 patients with positive serum findings. Conclusion: With regard to the existence of heterogenious clinical findings in large amount of patients with antibodies against Staphylococcal enterotoxins, the next study of Staphylococcal enterotoxins role in pathogenesis of wide spectrum of diseases is necessary.

        Key words: toxic shock syndrome, Staphylococcal enterotoxins, gyneacological inflammations