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  Česky / Czech version Čs. Fyziol., 51, 2002, No. 3, p. 122–128
 
Molecular Mechanisms of Lithium Biological Action 
Patočka J.1, Klár I.2, Strunecká A.3 

1Katedra toxikologie, Vojenská lékařská akademie, Hradec Králové, Katedra radiologie, Zdravotně sociální fakulta Jihočeské univerzity, České Budějovice 2Desitin Pharma, s.r.o., Praha 3Katedra fyziologie a vývojové biologie, Přírodovědecká fakulta UK, Praha
 


Summary:

       Lithium has the inhibitory effect on many enzymes and multiple effects on some physiological processes. Lithium is also highly effective in the treatment of bipolar disorder, however, the mechanism of lithium action in the treatment of this psychiatric disorder is still unknown. A number of lithium-sensitive enzymes and putative important biomolecules have been proposed as potential targets of lithium action and these mechanisms are discussed in this review.

        Key words: lithium, bipolar disorder, inositol monophosphatase, phosphoinositide signaling system, glycogen synthase kinase 3β, Wnt signaling
       

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