Case report of uncommon Behcet’s disease in our conditions of 52 years old female patient is described. She had been admitted in our department for dysfagia due to unhealed oral cavity ulcerations. Simultaneously, skin lesions of erythema nodosum-like and acne-like lesions, perigenital ulcerations, oligoarthritis and fever were present. Biochemistry revealed signs of non-specific inflammation. In the differential diagnosis a Crohn’s disease, pemphigus, lichen planus oral, MALT lymphoma of oral cavity, herpetic, cytomegalovirus and HIV infection and systemic lupus erythematodes were considered. For final diagnosis repeated tissue histology and imunohistoechmistry of oral nad skin lesions was conclusive. Diagnosis was made according to the exclusion of the above mentioned diseases and diagnostic criteria of Behcet’s disease fulfilment. Corticoosteroid and early azathioprin treatment was started after which fever, skin and oral lesions in a short time disappeared. After 4 weeks the patient was discharged. The authors stress to consider this disease in a home conditions especially in patients suffering from reccurent oral ulcerations.

        Key words: Behcet’s disease – immunosupression – oral ulceration