Objective: The aim of this paper is to provide a brief update review of current pharmacological agents used to treat women with GSI (Genuine Stress Incontinence). Design: Review article. Setting: Gynecological and Obstetric Clinic, 1. LF UK and VFN, Apolinářská 18, Prague 2. Results: Genuine stress urinary incontinence is the involuntary loss of urine associated with increasing of intraabdominal pressure (such as running, jumping, coughing, etc.). Although the pelvic fl oor muscle training, behavioral and surgical therapies are currently the mainstay of treating GSI, we believe that pharmacological treatment can help to increase the cure rate. With the advent of duloxetine, a serotonin (5-hydroxytryptamine [5-HT]) and norepinephrine (NE) reuptake inhibitor acting within the sacral spinal cord, the role of pharmacological treatment of GSI must be reviewed ev. re-examined.

        Key words: female urinary incontinence, genuine stress incontinence, duloxetine