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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitřní lékařství, 49, 2003, č. 1, s. 77 - 81 |
Cardiac Damage in
a Young Woman with Hodgkin’s Disease Surviving for a Prolonged Period after Combined Treatment
and Transplantation of Bone Marrow Vambera M.1, Jabali Y.2, Pešl L.1, Šetina M.3, Kabíčková E.4, Přádná J.5 1Kardiocentrum, Kardiologické oddělení, Nemocnice České Budějovice, přednosta prim. MUDr. F. Toušek 2Pediatrické oddělení, Nemocnice České Budějovice, přednosta prim. MUDr. V. Smrčka 3Kardiocentrum, Kardiochirurgické oddělení, Nemocnice České Budějovice, přednosta prim. MUDr. M. Šetina,CSc. 4Klinika dětské onkologie 2. lékařské fakulty UK a FN v Motole, Praha, přednosta prof. MUDr. J. Koutecký, DrSc. 5Oddělení patologické anatomie, Nemocnice České Budějovice, přednosta prim. MUDr. J. Přádná |
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Summary: The authors describe the disease of a 22-year-old woman treated from the age of 13 years on
account of Hodgkin’s lymphoma by irradiation and cytostatic treatment. On account of a relapse
of lymphoma at the age of 14 years megachemotherapy with subsequent transplantation of autologous
bone marrow. In the course of eight years of the follow up gradual developent of constrictive
pericarditis with exsudate. Concurrently progression of mitral insufficiency based on valvular
prolapse resulting from radiation. During the last two years refractory systemic hypertension
resistant to treatment. At the peak of the disease development of cardiac tamponade and cardiac
cachexia with anasarca. After anamnestic, clinical and haemodynamic analysis total pericardectomy
was indicated and mitral valve replacement performed. The operation led to improvement
of the patient’s condition, systemic hypertension receded completely. The patient is in permanent
remission.
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