Urine and blood concentrations of free and total morphin or 6-monoacetylmorphin were presen- ted in fatal cases of morphin type opiates abuse. A solid phase extraction method was developed for isolation of drugs and their metabolities from biological material which used Separcol small columns with non-polar contents SI C 18T. Thin layer chromatography with densitometry anabled screening for quality evaluations. Resultes were compared with those obtained by fluoropolari- zing immunodetection on Abbotts TDxFLx device. Posibility and cause of false positive results were discussed when using initial, screening, commercialy available immunotests.

        Key words: drug abuse - drug screening - morphin - 6-monoacetylmorphin - solid phase SI C 18T extraction - thin layer chromatography - densitometry - immunometods