Pulmonary hypertension is a condition characterized by elevation of the mean blood pressure in pulmonary artery above 25 mm Hg at rest or above 30 mm Hg during exercise. Pulmonary hypertension signs are not specific. They are frequently camouflaged by signs of a primary disease cau-sing pulmonary hypertension. That causes difficulties with diagnosing and often doesn't lead to recognition of pulmonary hypertension till pressure in pulmonary artery is difficult to manage therapeutically. Treatment of secondary pulmonary hypertension tries to affect primary disease. In patients with pulmonary artery hypertension with preserved vasoreactivity so called conventi-onal treatment is still recommended (vasodilatation treatment with calcium channels blockers, anticoagulation, oxygentherapy, treatment of heart failure). New ways of pharmacotheraphy rep-resent administration of prostacyclin, antagonists of endothelin receptors, and phosphodiesterase inhibitors. Nonpharmacology treatment of pulmonary hypertension includes balloon atrial sep-tostomy, lung transplantation, and in chronic thromboembolic pulmonary hypertension pulmonary endarterectomy. Current recommendations for pulmonary hypertension treatment concentrate especially on patients in functional classes NYHA III and IV. In less symptomatic patients there is usually lack of unambiguous clinical data needed for treatment. Owning to seri-ousness of the disease, its difficult diagnosing and frequently difficult treatment the globál trend is to concentrate care of patients with pulmonary hypertension in specialised centers. This problém systematically addresses a center at the 2 Clinic of Internal Medicíně of the lst Medical Fa-culty of the Charles University and the General Teaching Hospital in Prague in close cooperation with the Clinic of Cardiovascular Surgery at the General Teaching Hospital in Prague, and the transplantation center at the 3r Surgical Clinic of the Teaching Hospital Motol in Prague, the Czech Republic.

        Key words: Pulmonary hypertension - Diagnostics - Pharmacotherapy - Balloon atrial septostomy - Lung transplantation - Pulmonary endarterectomy