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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Čes. a slov. Neurol. Neurochir., 63/96, 2000, No. 3, p. 175–179. |
Interstitial
Brachytherapy for Recurrent Malignant Gliomas – Early Experience Odrážka K. 1 , Hobza V. 2 , Vaňásek J. 1 , Zouhar M. 1 , Stejskal J. 1 , Látr I. 2 , Žižka J. 3 1 Klinika radioterapie a onkologie FN, Hradec Králové 2 Neurochirurgická klinika FN, Hradec Králové 3 Radiodiagnostická klinika FN, Hradec Králové |
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Summary: Backgrounds: Interstitial brachytherapy (IBT) plays an important role in the treatment of recurrent
malignant gliomas and prolongs survival in selected patients. Design and Subjects: High-dose-rate
(HDR) IBT of brain tumours using magnetic resonance (MRI) planning – feasibility study. Methods and
Results: A locally recurrent anaplastic astrocytoma 50x30x25 mm in the left parietotemporal area was
revealed in a young man by magnetic resonance imaging (MRI). Three interstitial brachytherapy
catheters were stereotactically inserted. The catheters were positioned according to the Paris dosimet-
ric system. The MRI scans served for planning of treatment. Localization of the applicators was verified
on a simulator using the orthogonal technique. The dose was specified to the periphery of contrast
enhanced tumour and the reference isodose covered the volume of 31.4 ccm. The patient was treated
with 4x4,5 Gy on four consecutive days. The treatment was well tolerated. Conclusions: Our initial
experience suggests that MRI planning enables an accurate IBT procedure. To the author’s knowledge,
this is the first presentation of interstitial HDR brachytherapy for a brain tumour in the Czech
Republic.
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