The authors demonstrate neuromyotonia in a 72-year-old female patient with a thymoma where anti - bodies were detected against tension voltage gated channels and where improvement was achieved after immunoglobulin administration. Electrophysiological findings revealed axonal-demyelinization polyneuropathy and neuromyotonic discharges provoked solely by volitional contraction. Magnetic resonance and the clinical finding revealed signs of encephalopathy. Electrophysiological investigation located the neuromyotonic affection into the terminal portions of peripheral nerves. This is the first case of neuromyotonia associated with a thymoma with a confirmed autoimmune pathogenesis where in the electrophysiological finding neuromyotonic discharges were found which were evoked by volitional contraction only. The authors present an account of contemporary knowledge on this rare and curable syndrome.

        Key words: neuromyotonia, channelopathy, thymoma, myokymia