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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Trans. Hemat. dnes, 9, 2003, No. 2, p. 65–68. |
Preparation of Extract
of Peripheral Blood Progenitor Cells to the Autologous Transplantation in Patients with
Solid Tumours – Our Experience Pagáčová L.1, Nepomucká J.2, Antošová V.1, Greplová M.3, Kalanin J.4 1Autotransfuzní jednotka Institutu klinické a experimentální medicíny, Praha 2Onkologické oddělení FTN, Praha3Transfuzní oddělení FNKV, Praha4Laboratoř průtokové cytometrie Institutu klinické a experimentální medicíny, Praha |
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Summary: High - dose chemotherapy with autologous transplantation of peripheral blood progenitor cells is
a possible treatment for the high-risk oncology patients. Peripheral blood stem cells (PBSC) have been
separated on Autotransfusion detachment in IKEM Prague since November 1996. By the end of
September 2002, 64 patients (47 man and 17 women) with solid tumours were indicated for collections.
PBSC separations were commenced at value CD 34+ peripheral blood cells over 20 x 103/ml after
mobilization by combination of chemotherapy with growth factors - G-CSF (Neupogen in dose 15
µg/kg/day). There were 247 separations provided on the whole on the Haemonetics MCS 3p and MCS+
separators, respectively. Both types of separators were compared. All the patients were given extract
PBSC extracts back: 40 patients after the application of high – dose chemotherapy and 24 patients after
the application of only intensificated therapy. This procedure appears to be very perspective for this
group of patients in the future.
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