Objective: To evaluate influence of hormonal contraceptive drospirenone on premenstrual syndrome (PMS). Design: Overall summary of literature. Author affiliation: ADC Sanatorium, Praha. Methods: Review of scientific studies and publications. Conclusions: The author submitted current opinions on premenstrual syndrome, its classification, and treatment. The role of renin – aldosterone system in the genesis of PMS was described. Basic pharmacological characteristics of the remedy containing in one pill 30 mg of Ethinyl Estradiol (EE) and 3 mg of drospirenone are presented. Its therapeutic effects on somatic and psychological PMS symptoms are discussed.

        Key words: premenstrual syndrome – body weight – oedema – drospirenone.