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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 48, 2002, No. 5, p. 403-408 |
Specific Inhibitors of Type 2 Cycloogygenase Tomasová-Studýnková J. 3. lékařská fakulta UK, Revmatologický ústav, Praha, ředitel prof. MUDr. K Pavelka, |
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Summary: In the submitted review the author analyzes the ratio, function and role of two different forms of cycloogygenases - cycloogygenase type 1 and cycloogygenase type 2 - in the human organism.Special attention is devoted to speciflc inhibitory of cycloogygenase type 2. Speciflc inhibitoon of COX-2 is associated with a lower incidence of undesirable reactions while the antiinflammatory and analgetic effect is preserved. Celecogib and rofecogib - the oldest representatives of drugs from this group esere used in a number of clinical studies. The results of some of these studies are presented and commented.
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