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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
Journals - Article | |
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Česky / Czech version | Vnitř. Lék., 48, 2002, No. 6, p. 587-590 |
Barrett´s
Oesophagus Dolina J., Hep A., Díte P., Münzová H., Kunov ká M., Husová L., Plottová Z. Interní astroenterolo ická klinika, FN Brno, pracovište Bohunice, přednosta prof. MUDr. P. Díte, DrSc. |
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Summary: Barrett´ oesophagu is a premalignant metaplastic change of the oesophageal mucosa. Due to its
relation hip with oesophageal reflux disease and the development of adenomacarcinoma of the
oesophagu the problem arouse increasing interest. In the wide pathogene is of the disease most
probably the composite effect of the refluxed HCl content and duodenal juice play a part. In the
diagnosis in addition to fundamental method - endoscopy and histology - increasingly chromoendo
copy and fluorescent endoscopy are involved. Dispenarization of patient is esential and
depends on the degree of pathohistological epithelial change . Treatment of Barrett´ oesophagu
can be divided into conservative, where the drug of choice are protonspump inhibitor , and
surgical treatment. Promising is endoscopic ablation of the epithelium in combination with ubequent anti ecretory therapy.
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